Multi-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytes
نویسندگان
چکیده
منابع مشابه
Epigenetic mechanisms of metabolic memory in diabetes.
Diabetes affects 28.5 million people in the US.1 In addition, several million people with diabetes are estimated to be undiagnosed, thus increasing the risk for developing long-term complications, including macrovascular diseases and end-stage renal disease in a fairly significant fraction of the population. Type 1 diabetes, an autoimmune disease that mainly afflicts children, is characterized ...
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100-250 words) How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses? Furthermore how do cells of different phenotypes differentiate reproducibly from a single fertilized egg? These are fundamental problems in developmental biology. Epigenetic histone modifications...
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Epigenetic regulation of cellular identity and function is at least partly achieved through changes in covalent modifications on DNA and histones. Much progress has been made in recent years to understand how these covalent modifications affect cell identity and function. Despite the advances, whether and how epigenetic factors contribute to memory formation is still poorly understood. In this ...
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ژورنال
عنوان ژورنال: BMC Immunology
سال: 2015
ISSN: 1471-2172
DOI: 10.1186/s12865-015-0089-9